{"id":304,"date":"2014-04-22T13:15:25","date_gmt":"2014-04-22T13:15:25","guid":{"rendered":"http:\/\/pbwww.che.sbg.ac.at\/wordpress\/?page_id=304"},"modified":"2020-09-03T13:44:21","modified_gmt":"2020-09-03T12:44:21","slug":"publications","status":"publish","type":"page","link":"https:\/\/pbwww.services.came.sbg.ac.at\/?page_id=304","title":{"rendered":"Publications"},"content":{"rendered":"

2020<\/h2>\n

A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate. da Silva ES, Aglas L, Pinheiro CS, de Andrade Belitardo EMM, Silveira EF, Huber S, Torres RT, Wallner M, Briza P, Lackner P, Laimer J, Luis Pacheco GC, Cruz \u00c1A, Alc\u00e2ntara-Neves NM, Ferreira F. Clin Exp Allergy<\/em> 2020. DOI: 10.1111\/cea.13611<\/a>. PMID: 32314444<\/a><\/p>\n

In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization. Winter P, Stubenvoll S, Scheiblhofer S, Joubert IA, Strasser L, Briganser C, Soh WT, Hofer F, Kamenik AS, Dietrich V, Michelini S, Laimer J, Lackner P, Horejs-Hoeck J, Tollinger M, Liedl KR, Brandstetter J, Huber CG, Weiss R. Front. Immunol.<\/em> 2020. DOI: 10.3389\/fimmu.2020.01824<\/a><\/p>\n

The Cell Wall PAC (Proline-Rich, Arabinogalactan Proteins, Conserved Cysteines) Domain-Proteins Are Conserved in the Green Lineage.
\nNguyen-Kim H, San Clemente H, Laimer J, Lackner P, Gadermaier G, Dunand C, Jamet E. Int J Mol Sci.<\/em> 2020. DOI: 10.3390\/ijms21072488<\/a>. PMID: 32260156<\/a><\/p>\n

2019<\/h2>\n

Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants. Eichhorn S, H\u00f6rschl\u00e4ger A, Steiner M, Laimer J, Jensen BM, Versteeg SA, Pablos I, Briza P, Jongejan L, Rigby N, Asturias JA, Portol\u00e9s A, Fernandez-Rivas M, Papadopoulos NG, Mari A, Poulsen LK, Lackner P, van Ree R, Ferreira F, Gadermaier G. Mol Nutr Food Res.<\/em> 2019. DOI: 10.1002\/mnfr.201900336<\/a>. PMID: 31207117<\/a><\/p>\n

Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly. Domingues FS, K\u00f6nig E, Schwienbacher C, Volpato CB, Picard A, Cantaloni C, Mascalzoni D, Lackner P, Heimbach A, Hoffmann P, Stanzial F, Hicks AA, Parmeggiani L, Benedicenti F, Pellegrin S, Casara G, Pramstaller PP. Seizure.<\/em> 2019. DOI: 10.1016\/j.seizure.2018.12.021<\/a>. PMID: 30818181<\/a><\/p>\n

2018<\/h2>\n

Dissecting the subcellular membrane proteome reveals enrichment of H+ (co-)transporters and vesicle trafficking proteins in acidic zones of Chara internodal cells. Pertl-Obermeyer H, Lackner P, Schulze WX, Hoepflinger MC, Hoeftberger M, Foissner I, Obermeyer G. PLoS One.<\/em> 2018. DOI: 10.1371\/journal.pone.0201480<\/a>. PMID: 30157181<\/a><\/p>\n

The Pollen Plasma Membrane Permeome Converts Transmembrane Ion Transport Into Speed. Pertl-Obermeyer H, Lackner P, Dunlop JWC Obermeyer G. Advances in Botanical Research. Elsevier.<\/em> 2018. DOI: 10.1016\/bs.abr.2018.09.008<\/a><\/p>\n

Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma. Sternberg C, Gruber W, Eberl M, Tesanovic S, Stadler M, Elmer DP, Schlederer M, Grund S, Roos S, Wolff F, Kaur S, Mangelberger D, Lehrach H, Hache H, Wierling C, Laimer J, Lackner P, Wiederstein M, Kasper M, Risch A, Petzelbauer P, Moriggl R, Kenner L, Aberger F. Int J Cancer.<\/em> 2018 Jul 10. DOI: 10.1002\/ijc.31724<\/a>. PMID: 29987839<\/a><\/p>\n

2017<\/h2>\n

Multi-Approach Analysis for the Identification of Proteases within Birch Pollen. McKenna OE, Posselt G, Briza P, Lackner P, Schmitt AO, Gadermaier G, Wessler S, Ferreira F. Int J Mol Sci.<\/em> 2017 Jul 4;18(7). pii: E1433. doi: 10.3390\/ijms18071433. PMID: 28677627<\/a><\/p>\n

Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen. H\u00f6llbacher B, Schmitt AO, Hofer H, Ferreira F, Lackner P. Int J Mol Sci.<\/em> 2017 Jun 5;18(6). pii: E1199. doi: 10.3390\/ijms18061199. PMID: 28587253<\/a><\/p>\n

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules. Santos da Silva E, Asam C, Lackner P, Hofer H, Wallner M, Silva Pinheiro C, Alc\u00e2ntara-Neves NM, Ferreira F. Int Arch Allergy Immunol.<\/em> 2017 Apr 29;172(4):203-214. doi: 10.1159\/000464325. PMID: 28456805<\/a><\/p>\n

Influence of protein fold stability on immunogenicity and its implications for vaccine design. Scheiblhofer S, Laimer J, Machado Y, Weiss R, Thalhamer J. Expert Rev Vaccines<\/em> 2017 May;16(5):479-489. doi: 10.1080\/14760584.2017.1306441. PMID: 28290225<\/a><\/p>\n

2016<\/h2>\n

Tackling Bet v 1 and associated food allergies with a single hybrid protein. Hofer H, Asam C, Hauser M, Nagl B, Laimer J, Himly M, Briza P, Ebner C, Lang R, Hawranek T, Bohle B, Lackner P, Ferreira F, Wallner M. J Allergy Clin Immunol.<\/em> 2016 Dec 7. pii: S0091-6749(16)31441-5. doi: 10.1016\/j.jaci.2016.09.055. PMID: 27939703<\/a><\/p>\n

MAESTROweb: a web server for structure based protein stability prediction. Laimer J, Hiebl-Flach J, Lengauer D, Lackner P. Bioinformatics<\/em> 2016 Jan 6. pii: btv769. doi: 10.1093\/bioinformatics\/btv769. PMID: 26743508<\/a><\/p>\n

2015<\/h2>\n

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen. Machado Y, Freier R, Scheiblhofer S, Thalhamer T, Mayr M, Briza P, Grutsch S, Ahammer L, Fuchs JE, Wallnoefer HG, Isakovic A, Kohlbauer V, Hinterholzer A, Steiner M, Danzer M, Horejs-Hoeck J, Ferreira F, Liedl KR, Tollinger M, Lackner P, Johnson CM, Brandstetter H, Thalhamer J, Weiss R. J Allergy Clin Immunol.<\/em> 2015 Nov 11. pii: S0091-6749(15)01366-4. doi: 10.1016\/j.jaci.2015.09.026. PMID: 26559323<\/a><\/p>\n

MAESTRO – multi agent stability prediction upon point mutations. Laimer J, Hofer H, Fritz M, Wegenkittl S, Lackner P.  BMC Bioinformatics<\/em> 2015, 16:116 doi:10.1186\/s12859-015-0548-6. PMID: 25885774<\/a><\/p>\n

2014<\/h2>\n

Development of a hypoallergenic and immunogenic Pru p 3 proline variant for treatment of peach allergy.  Eichhorn S, Steiner M, Laimer J, Lackner P, Zuidmeer-Jongejan L, Briza P,  Mari A, van Ree R,  Ferreira F, Gadermaier G. Clinical and Translational Allergy 2014, 4<\/strong>(Suppl 2):O22 doi:10.1186\/2045-7022-4-S2-O22<\/p>\n

2013<\/h2>\n

Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis. Roulias A, Pichler U, Hauser M, Himly M, Hofer H, Lackner P, Ebner C, Briza P, Bohle B, Egger M, Wallner M, Ferreira F. Allergy. 2013 Nov 14. doi: 10.1111\/all.12306.
\nPMID: 24224690<\/a><\/p>\n

D-Light on promoters: a client-server system for the analysis and visualization of cis-regulatory elements. Laimer J, Zuzan CJ, Ehrenberger T, Freudenberger M, Gschwandtner S, Lebherz C, Lackner P. BMC Bioinformatics. 2013 Apr 24;14:140. doi: 10.1186\/1471-2105-14-140.
\nPMID: 23617301<\/a><\/p>\n

2012<\/h2>\n

Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells. Karle AC, Oostingh GJ, Mutschlechner S, Ferreira F, Lackner P, Bohle B, Fischer GF, Vogt AB, Duschl A. PLoS One. 2012;7(2):e31483. doi: 10.1371\/journal.pone.0031483. Epub 2012 Feb 14.
\nPMID: 22348091<\/a><\/p>\n

2010<\/h2>\n

Thalhamer T, Dobias H, Stepanoska T, Pr\u00f6ll M, Stutz H, Dissertori O, Lackner P, Ferreira F, Wallner M, Thalhamer J, Hartl A. Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening. J Allergy Clin Immunol. 2010 Apr;125(4):926-934.e10.
\nPMID: 20371399<\/a><\/p>\n

Mutschlechner S, Egger M, Briza P, Wallner M, Lackner P, Karle A, Vogt AB, Fischer GF, Bohle B, Ferreira F. Naturally processed T cell-activating peptides of the major birch pollen allergen. J Allergy Clin Immunol. 2010 Mar;125(3):711-8, 718.e1-718.e2. Epub 2010 Feb 4.
\nPMID: 20132976<\/a><\/p>\n

2009<\/h2>\n

Bindreither D, Lackner P. Structural diversity of calcium binding sites. In: General physiology and biophysics. Gen. Physiol. Biophys. 2009; Vol.28, Focus Issue.<\/p>\n

Berbalk C, Schwaiger CS, Lackner P. Accuracy analysis of multiple structure alignments. Protein Sci 2009 Oct;18(10):2027-35.
\nPMID: 19621383<\/a><\/p>\n

P\u00f6ll V, Denk U, Shen HD, Panzani RC, Dissertori O, Lackner P, Hemmer W, Mari A, Crameri R, Lottspeich F, Rid R, Richter K, Breitenbach M, Simon-Nobbe B. The vacuolar serine protease, a cross-reactive allergen from Cladosporium herbarum. Mol Immunol. 2009 Apr;46(7):1360-73. Epub 2009 Jan 21.
\nPMID: 19162325<\/a><\/p>\n

Klinglmayr E, Hauser M, Zimmermann F, Dissertori O, Lackner P, Wopfner N, Ferreira F, Wallner M. Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with food allergens. Allergy 2009 Apr;64(4):647-51. Epub 2009 Jan 9.
\nPMID: 19154550<\/a><\/p>\n

2008<\/h2>\n

Mayr G,Lepperdinger G, Lackner P. Automated quantitative assessment of proteins\u2019 biological function in protein knowledge bases. Hindawi Publishing Corporation, Adv Bioinformatics. 2008:897019. Epub 2008 Jun 30.
\nHINDAWI AIP: 897019 <\/a>
\nPMID: 19920991<\/a><\/p>\n

Radauer C, Lackner P, Breiteneder H. The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. BMC Evolutionary Biology 2008 Oct 15;8:286.
\nPMID: 18922149<\/a><\/p>\n

2007<\/h2>\n

Mayr G, Domingues FS, Lackner P.Comparative analysis of protein structure alignments. BMC Struct Biol. 2007 Jul 26;7:50.
\nPMID: 17672887 <\/a>[PubMed – indexed for MEDLINE]<\/p>\n

Wallner M, St\u00f6cklinger A, Thalhamer T, Bohle B, Vogel L, Briza P, Breiteneder H, Vieths S, Hartl A, Mari A, Ebner C, Lackner P, Hammerl P, Thalhamer J, Ferreira F. Allergy multivaccines created by DNA shuffling of tree pollen allergens. J Allergy Clin Immunol. 2007 Aug;120(2):374-80. Epub 2007 Jul 10.
\nPMID: 17624416 <\/a>[PubMed – indexed for MEDLINE]<\/p>\n

Wopfner N, Dissertori O, Ferreira F, Lackner P. Calcium-binding proteins and their role in allergic diseases. Immunol Allergy Clin North Am. 2007 Feb;27(1):29-44.
\nPMID: 17276877 <\/a>[PubMed – in process]<\/p>\n

2005<\/h2>\n

Henn IH, Gostner JM, Lackner P, Tatzelt J, Winklhofer KF. Pathogenic mutations inactivate parkin by distinct mechanisms. J Neurochem. 2005 Jan;92(1):114-22.
\nPMID: 15606901 <\/a>[PubMed – indexed for MEDLINE]<\/p>\n

2004<\/h2>\n

Prlic A, Domingues FS, Lackner P, Sippl MJ. WILMA-automated annotation of protein sequences. Bioinformatics. 2004 Jan 1;20(1):127-8.
\nPMID: 14693821 <\/a>[PubMed – indexed for MEDLINE]<\/p>\n

Wiederstein M., Lackner P., Kienberger F., Sippl M. (2004) Directed in silico Mutagenesis. Evolutionary Methods in Biotechnology: Wiley-VCH, 153-175 . Brakmann S. & Schwienhorst A. (eds)<\/p>\n

2002<\/h2>\n

Amberger A, Schneeberger S, Hernegger G, Brandacher G, Obrist P, Lackner P, Margreiter R, Mark W. Gene expression profiling of prolonged cold ischemia and reperfusion in murine heart transplants. Transplantation. 2002 Nov 27;74(10):1441-9.
\nPMID: 12451246 <\/a>[PubMed – indexed for MEDLINE]<\/p>\n

Lackner P. (2002) Tailor-made recombinant proteins: from computational analysis to practical application. Recent Research Developments. Proteins, Volume 1.Transworld Research Network. 2002, Trivandrum, India<\/p>\n

2000 and earlier<\/h2>\n

Domingues F., Lackner P., Andreeva A., Sippl M. (2000) Structure based evaluation of sequence comparison and fold recognition alignment accuracy. The Journal of Molecular Biology 297(4), 1003-1013, London<\/p>\n

Lackner P., Koppensteiner W., Sippl M., Domingues F. (2000) ProSup: a refined tool for protein structure alignment. Protein Engineering 13(11): 745-752<\/p>\n

Domingues FS, Koppensteiner WA, Jaritz M, Prlic A, Weichenberger C, Wiederstein M, Floeckner H, Lackner P, Sippl MJ. Sustained performance of knowledge-based potentials in fold recognition. Proteins. 1999;Suppl 3:112-20.
\nPMID: 10526359<\/a><\/p>\n

Lackner P, Koppensteiner WA, Domingues FS, Sippl MJ. Automated large scale evaluation of protein structure predictions. Proteins. 1999;Suppl 3:7-14.
\nPMID: 10526347<\/a><\/p>\n

Sippl MJ, Ortner M, Jaritz M, Lackner P, Flockner H. Helmholtz free energies of atom pair interactions in proteins. Fold Des. 1996;1(4):289-98.
\nPMID: 9079391<\/a><\/p>\n

Flockner H, Braxenthaler M, Lackner P, Jaritz M, Ortner M, Sippl MJ. Progress in fold recognition. Proteins. 1995 Nov;23(3):376-86.
\nPMID: 8710830<\/a><\/p>\n

Sippl MJ, Hendlich M, Lackner P. Assembly of polypeptide and protein backbone conformations from low energy ensembles of short fragments: development of strategies and construction of models for myoglobin, lysozyme, and thymosin beta 4. Protein Sci. 1992 May;1(5):625-40.
\nPMID: 1304362<\/a><\/p>\n

Hendlich M, Lackner P, Weitckus S, Floeckner H, Froschauer R, Gottsbacher K, Casari G, Sippl MJ. Identification of native protein folds amongst a large number of incorrect models. The calculation of low energy conformations from potentials of mean force. J Mol Biol. 1990 Nov 5;216(1):167-80.
\nPMID: 2121999<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

2020 A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate. da Silva ES, Aglas L, Pinheiro CS, de Andrade Belitardo EMM, Silveira EF, Huber S, Torres RT, Wallner M, Briza P, Lackner P, Laimer J, Luis Pacheco GC, Cruz \u00c1A, Alc\u00e2ntara-Neves NM, Ferreira F. Clin Exp Allergy 2020. DOI: 10.1111\/cea.13611. PMID: … Continue reading Publications<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/pages\/304"}],"collection":[{"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=304"}],"version-history":[{"count":28,"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/pages\/304\/revisions"}],"predecessor-version":[{"id":755,"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=\/wp\/v2\/pages\/304\/revisions\/755"}],"wp:attachment":[{"href":"https:\/\/pbwww.services.came.sbg.ac.at\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}